In patients or tumors with LKB1 loss, excessive metabolic or oxidative stress (e.g., from fasting, ischemia, intense exercise, even metformin in some cases) could backfire, as the cell has lost its core stress adaptation switch.
Avoiding extreme stress (physiologic, metabolic, oxidative) also makes sense. NAD⁺ boosters can fuel tumors if mTOR is dominant and AMPK is suppressed (context is key). In your case, your AMPK is severely suppressed. The best form is IV NAD+; the best form of oral NAD+ is NMN. The highest quality is Wonderfeel Youngr™ NMN / NMN at 600mg-1000mg a day. In your case, you need an excellent defensive strategy.
You asked the most sophisticated question. While mTOR ( there are actually two mTOR pathways) in the second half of life when over stimulated lead to cancer. You don't want to shut it down completely. mTOR plays a huge part in muscle mass and tone which we all need when we get older. We can't measure mTOR directly but these are some tests that we can estimate if the mTOR is in over drive: Insulin >12 µIU/mL;IGF-1: 240 ng/mL (Anabolic signaling); CRP >3.2 mg/L (Inflammatory driver of mTOR)
BHB (ketones)0.1 mmol/L. You would want a higher number. A low number showed No ketosis ( mTOR unchecked)
GKI>9 Poor metabolic flexibility. My blood work is kind of designed to see the balance between AMPK and mTOR. Some of my colleagues take Rapamycin 2-3mg a week to shut down their mTOR pathway.
There is a place near where we live where an ex-nurse does this. I do it every 6 months with incredible results: an immediate feeling of mental clarity and Tight (as in tight stomach)
Thank you Dr. Phan.
So I would assume that those with the loss of LBK1 that it would be important to avoid extreme stress if possible?
Also, what do you think of NAD+ oral supplements?
In patients or tumors with LKB1 loss, excessive metabolic or oxidative stress (e.g., from fasting, ischemia, intense exercise, even metformin in some cases) could backfire, as the cell has lost its core stress adaptation switch.
Avoiding extreme stress (physiologic, metabolic, oxidative) also makes sense. NAD⁺ boosters can fuel tumors if mTOR is dominant and AMPK is suppressed (context is key). In your case, your AMPK is severely suppressed. The best form is IV NAD+; the best form of oral NAD+ is NMN. The highest quality is Wonderfeel Youngr™ NMN / NMN at 600mg-1000mg a day. In your case, you need an excellent defensive strategy.
Thank you! Wow, this is complicated. Thank you so much for all your help.
How would I know if mTOR is dominant?
You asked the most sophisticated question. While mTOR ( there are actually two mTOR pathways) in the second half of life when over stimulated lead to cancer. You don't want to shut it down completely. mTOR plays a huge part in muscle mass and tone which we all need when we get older. We can't measure mTOR directly but these are some tests that we can estimate if the mTOR is in over drive: Insulin >12 µIU/mL;IGF-1: 240 ng/mL (Anabolic signaling); CRP >3.2 mg/L (Inflammatory driver of mTOR)
BHB (ketones)0.1 mmol/L. You would want a higher number. A low number showed No ketosis ( mTOR unchecked)
GKI>9 Poor metabolic flexibility. My blood work is kind of designed to see the balance between AMPK and mTOR. Some of my colleagues take Rapamycin 2-3mg a week to shut down their mTOR pathway.
Thank you! Very helpful!
I believe competitive athletes, who train intensely, at a young age , have multiple issues later in life . Thank you for this discussion Dr. Phan .
Great article. I cannot have metformin or berberine, but I do have quercetin. Right now I am in good health but I will keep that in mind !
Decided to look it up! Wow! https://www.qmul.ac.uk/media/news/2025/science-and-engineering/se/caffeine-could-slow-cellular-ageing-new-research-shows-how.html
I recently read that is coffee an AMPK activator? If so, I wonder if that is why coffee enemas are good for cancer.
There is a place near where we live where an ex-nurse does this. I do it every 6 months with incredible results: an immediate feeling of mental clarity and Tight (as in tight stomach)
Thank you. You are so smart and very blessed. I feel blessed getting to read your knowledge.